UFR des Sciences Pharmaceutiques de Lille
Nom : LEBÈGUE
Prénom : Nicolas
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Equipe de recherche
Intitulé : équipe "Brain Biology and Chemistry", Lille Neuroscience and Cognition
Inserm UMR-S1172
Thématiques : maladies neurologiques, santé mentale et neuroendocrinologie
Mots clés : Chimie médicinale, Drug Design, chimie hétérocyclique, interaction protéine-protéine, biophysique, SIRT1, LRRK2, TEAD
Principales publications
- MARCHAND A, SARCHIONE A, ATHANASOPOULOS PS, BAUDERLIQUE-LE ROY H, GOVEAS L, MAGNEZ R, DROUYER M, EMANUELE M, HO FY, LIBERELLE M, MELNYK P, LEBEGUE N, THURU X, NICHOLS RJ, GREGGIO E, KORTHOLT A, GALLI T, CHARTIER-HARLIN MC, TAYMANS JM. “A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively”. Cells, 2022, 11(6):1018.
- STOUP, N.; LIBERELLE, M.; SCHULZ, C.; CAVDARLI, S.; VASSEUR, R.; MAGNEZ, R.; LAHDAOUI, F.; SKRYPEK, N.; PERETTI, F.; FRÉNOIS, F.; THURU, X.; MELNYK, P.; RENAULT, N.; JONCKHEERE, N.; LEBEGUE N.; VAN SEUNINGEN, I. “The EGF domains of MUC4 oncomucin mediate HER2 binding affinity and promote pancreatic cancer cell tumorigenesis”. Cancers 2021, 13:5746.
- Stoup, N.; Liberelle, M.; Schulz, C.; Cavdarli, S.; Vasseur, R.; Magnez, R.; Lahdaoui, F.; Skrypek, N.; Peretti, F.; Frénois, F.; Thuru, X.; Melnyk, P.; Renault, N.; Jonckheere, N.; Lebegue N.; Van seuningen, I. The EGF domains of MUC4 oncomucin mediate HER2 binding affinity and promote pancreatic cancer cell tumorigenesis. Cancers 2021, 13, 5746.
- LIBERELLE M, JONCKHEERE N, MELNYK P, Van SEUNINGEN I, LEBÈGUE N. "EGF-Containing Membrane-Bound Mucins: A Hidden ErbB2 Targeting Pathway?" J Med Chem. 2020 63(10):5074-5088.
- LIBERELLE M, MAGNEZ R, THURU X, BENCHEIKH Y, RAVEZ S, QUENON C, DRUCBERT AS, FOULON C, MELNYK P, Van SEUNINGEN I, LEBÈGUE N. "MUC4-ErbB2 Oncogenic Complex: Binding studies using Microscale Thermophoresis". Sci Rep. 2019 9(1):16678
- PIRAT C, DACQUET C, LECLERC V, HENNUYER N, BEUCHER-GAUDIN M, ZANIRATO G, GÉANT A, STAELS B, KTORZA A, FARCE A, CAIGNARD DH, BERTHELOT P, LEBEGUE N. "Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression" Eur J Med Chem. 2017 Sep 8;137:310-326.
- SEGAOULA Z, LECLERCQ J, VERONES V, FLOUQUET N, LECOEUR M, ACH L, RENAULT N, BARCZYK A, MELNYK P, BERTHELOT P, THURU X, LEBEGUE N. "Synthesis and Biological Evaluation of N-[2-(4-Hydroxyphenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide (ABT-751) Tricyclic Analogues as Antimitotic and Antivascular Agents with Potent in Vivo Antitumor Activity". J Med Chem. 2016 59(18):8422-40.
- PIRAT C, FARCE A, LEBÈGUE N, RENAULT N, FURMAN C, MILLET R, YOUS S, SPECA S, BERTHELOT P, DESREUMAUX P, CHAVATTE P. "Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators". J Med Chem. 2012 55(9):4027-61