UFR des Sciences Pharmaceutiques de Lille
Nom : CHAVATTE
Prénom : Philippe
Equipe de recherche
Intitulé : Therapeutic Innnovation Targeting Inflammation
Numéro : Lille Inflammation Research International Center - UMR 995 Inserm / Université Lille 2 / CHRU de Lille
Thématiques : agonistes CB2, antagonistes P2X7, antagonistes NOD1, antagonistes RAGE, agonistes AhR, agonistes PPARs
Mots clés : Inflammation, MICI, innovation thérapeutique, chimie médicinale, bioanalyse, modélisation moléculaire, vectorisation
Principales publications
- C. Pirat, A. Farce, N. Lebègue, N. Renault, C. Furman, R. Millet, S. Yous, S. Speca, P. Berthelot, P. Desreumaux, P. Chavatte, "Targeting Peroxisome Proliferator-Activated Receptors (PPARs): development of modulators", Journal of Medicinal Chemistry, 2012, 55, 4027-4061 .
- J. El Bakali, P. Gilleron, M. Body-Malapel, M. Roxane, G.G. Muccioli, M. Djouina, I. Caron, E. Lipka, V. Andrzejak-Lucas, F. Klupsch, A. Lemoine, C. Furman, D.M. Lambert, P. Chavatte, P. Desreumaux, R. Millet, "4-Oxo-1,4-dihydropyridines as selective CB2 cannabinoid receptor ligands. Part 2: toward new therapeutic agents in the treatment of colitis", Journal of Medicinal Chemistry, 2012, 50, 8948-8952.
- N. Renault, X. Laurent, A. Farce, J. El Bakali, R. Mansouri, P. Gervois, R. Millet, P. Desreumaux, C. Furman, P. Chavatte, "Virtual screening of CB2 receptor agonists from bayesian network and high-throughput docking: structural insights into agonist-modulated GPCR features", Chemical Biology & Drug Design, 2013, 81, 442-454.
- X. Laurent, N. Renault, A. Farce, B. Bertin, S. Speca, O. Milhomme, R. Millet, P. Desreumaux, E. Hénon, P. Chavatte, "Switching iNKT response from anticancerous to anti-inflammatory effect: molecular bases", Journal of Medicinal Chemistry, 2014, 57, 5489-5508.
- X. Laurent, N. Renault, A. Farce, P. Chavatte, E. Hénon, "Relationships between Th1 or Th2 iNKT cell activity and structures of CD1d-antigen complexes: META-ANALYSIS of CD1d-GLYCOLIPIDS DYNAMICS SIMULATIONS", PLOS Computational Biology, 10, 1-15, 2014.