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UFR des Sciences Pharmaceutiques de Lille

 

Nom : CHAVATTE

Prénom : Philippe

 

mini logo afect  Equipe de recherche 

Intitulé : Therapeutic Innnovation Targeting Inflammation

Numéro : Lille Inflammation Research International Center - UMR 995 Inserm / Université Lille 2 / CHRU de Lille  

Thématiques : agonistes CB2, antagonistes P2X7, antagonistes NOD1, antagonistes RAGE, agonistes AhR, agonistes PPARs

Mots clés : Inflammation, MICI, innovation thérapeutique, chimie médicinale, bioanalyse, modélisation moléculaire, vectorisation

mini logo afect  Principales publications

  1. C. Pirat, A. Farce, N. Lebègue, N. Renault, C. Furman, R. Millet, S. Yous, S. Speca, P. Berthelot, P. Desreumaux, P. Chavatte, "Targeting Peroxisome Proliferator-Activated Receptors (PPARs): development of modulators", Journal of Medicinal Chemistry, 2012, 55, 4027-4061 .
  2. J. El Bakali, P. Gilleron, M. Body-Malapel, M. Roxane, G.G. Muccioli, M. Djouina, I. Caron,  E. Lipka, V. Andrzejak-Lucas, F. Klupsch, A. Lemoine, C. Furman, D.M. Lambert, P. Chavatte, P. Desreumaux, R. Millet, "4-Oxo-1,4-dihydropyridines as selective CB2 cannabinoid receptor ligands. Part 2: toward new therapeutic agents in the treatment of colitis", Journal of Medicinal Chemistry, 2012, 50, 8948-8952.
  3. N. Renault, X. Laurent, A. Farce, J. El Bakali, R. Mansouri, P. Gervois, R. Millet, P. Desreumaux, C. Furman, P. Chavatte, "Virtual screening of CB2 receptor agonists from bayesian network and high-throughput docking: structural insights into agonist-modulated GPCR features", Chemical Biology & Drug Design, 2013, 81, 442-454. 
  4. X. Laurent, N. Renault, A. Farce, B. Bertin, S. Speca, O. Milhomme, R. Millet, P. Desreumaux, E. Hénon, P. Chavatte, "Switching iNKT response from anticancerous to anti-inflammatory effect: molecular bases", Journal of Medicinal Chemistry, 2014, 57, 5489-5508.
  5. X. Laurent, N. Renault, A. Farce, P. Chavatte, E. Hénon, "Relationships between Th1 or Th2 iNKT cell activity and structures of CD1d-antigen complexes: META-ANALYSIS of CD1d-GLYCOLIPIDS DYNAMICS SIMULATIONS", PLOS Computational Biology, 10, 1-15, 2014. 

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